Company Information
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking an Senior Scientist of Immunology as part of the Research & Early Development team based in Philadelphia, PA.
Role Overview
Legend Biotech is an international commercial stage biopharmaceutical company focused on the discovery and development of novel cell therapies for oncology and autoimmune disease (AID) indications. We are seeking a Senior Scientist who will contribute to our growing pipeline of innovative cell therapy in AID area.
Expertise in immunology and/or oncology is required. The ideal candidate will be a highly motivated individual who enjoys fast paced biotech environment. You thrive in a collaborative work environment and are skilled at advancing multiple projects concurrently. Knowledge of state-of-art immunotherapy and its applications. As part of the Legend Biotech R&D team and under minimal supervision, you will be responsible for timely execution and delivery of projects in our discovery pipeline.
Key Responsibilities
- Isolate immune cells from leukopak or blood from healthy donors or patients, expand them and measure their phenotype using multiple color flow cytometry and perform other functional assays including but not limited to ELISA
- Package and titer engineered viruses to infect immune cells in vitro and in vivo; Characterize virus particle with protein and PCR based assays; Measure transduction rate using flow and VCN analysis
- Develop and optimize immunoassays to detect host immune response to the virus particles
- Perform experiments to examine the persistence of CAR-T cells in vitro and in vivo
- Deliver result to meet timeline with accountability
- Maintain compliance with GLP and EHS protocols
- Prepare and present reports, publications, oral presentations and patent application documents
Requirements
- Ph. D. in immunology, oncology or related fields
- 2-4 years of experience in the field of cell therapy, immunology or AID
- Experience with in vivo CAR-T and/or deep understanding of AID is preferred
- Extensive experience in cellular and immune cell-based analytics and assay development including, but not limited to advanced multi-parameter flow-cytometry, immunogenicity assay such as mixed lymphocyte reaction assay, cytotoxicity assay, cytokine release ELISA/MSD multiplex assay
- Extensive experience of lentivirus engineering, packaging, tittering and related delivery methods
- Experience with in vivo tissue/cell-specific gene delivery in animal model is a plus
- Genome editing experience is a plus
- Deep knowledge of immunology and immunotherapy
- Ability to plan and timely execute of research projects
- Track record of productivity evidenced by publications or patents
- Strong technical skills and problem-solving skills
- Excellent verbal and written communication skills
- Ability to operate independently and collaborate in a team environment
- Language: English
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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.
Legend Biotech maintains a drug-free workplace.
